Applying Emax model and bivariate thin plate splines to assess drug interactions.

نویسندگان

  • Maiying Kong
  • J Jack Lee
چکیده

We review the semiparametric approach previously proposed by Kong and Lee and extend it to a case in which the dose-effect curves follow the Emax model instead of the median effect equation. When the maximum effects for the investigated drugs are different, we provide a procedure to obtain the additive effect based on the Loewe additivity model. Then, we apply a bivariate thin plate spline approach to estimate the effect beyond additivity along with its 95 per cent point-wise confidence interval as well as its 95 per cent simultaneous confidence interval for any combination dose. Thus, synergy, additivity, and antagonism can be identified. The advantages of the method are that it provides an overall assessment of the combination effect on the entire two-dimensional dose space spanned by the experimental doses, and it enables us to identify complex patterns of drug interaction in combination studies. In addition, this approach is robust to outliers. To illustrate this procedure, we analyzed data from two case studies.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A Comparison of Thin Plate and Spherical Splines with Multiple Regression

Thin plate and spherical splines are nonparametric methods suitable for spatial data analysis. Thin plate splines acquire efficient practical and high precision solutions in spatial interpolations. Two components in the model fitting is considered: spatial deviations of data and the model roughness. On the other hand, in parametric regression, the relationship between explanatory and response v...

متن کامل

Bivariate splines for ozone concentration forecasting

In this paper, we forecast ground level ozone concentrations over the USA, using past spatially distributed measurements and the functional linear regression model. We employ bivariate splines defined over triangulations of the relevant region of the USA to implement this functional data approach in which random surfaces represent ozone concentrations. We compare the least squares method with p...

متن کامل

Spatial Risk Smoothing

This paper describes a method for estimating insurance claims or risk premiums allowing for spatial dependence as well as explanatory factors. The concepts are related to those used for graduation of mortality tables using cubic splines but extended to spatial dependence as found in many insurance products. Firstly techniques for measuring spatial dependence are reviewed. Then models with bivar...

متن کامل

Finite Element Thin Plate Splines for Data Mining Applications

Thin plate splines have been used successfully to model curves and surfaces. A new application is in data mining where they are used to model interaction terms. These interaction splines break the \curse of dimensionality" by reducing the high-dimensional nonparametric regression problem to the determination of a set of interdependent surfaces. However, the determination of the corresponding th...

متن کامل

Elastic Spline Models for Human Cardiac Motion Estimation

Elastic splines (including dynamic \snakes" and elastic contours), minimising an energy norm of the membrane and/or thin-plate types, have been used to model many surfaces in visual reconstruction and related biomedical applications. In this paper, we model the displacement of the material between successive cardiac images using vector splines. We deene a family of elastic splines. These spline...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Frontiers in bioscience

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2010